![]() We’re probably not going to be able to cover all the genotypes of cancer. “So you’d need a sensor that was specific for each change. “Detecting cancer is quite difficult because there’re so many different changes that you could possibly be looking for,” Woods tells Cosmos. The upside suggested by the study is that DNA fragments of potential cancer don’t need to be isolated and purified to confirm the presence of disease.īut while colorectal cancer was targeted in this study, the project’s future may lie elsewhere.īiomedical scientist Susan Woods, one of SAHMRI’s co-senior authors on the study who is also based at the Adelaide Medical School, suggests CATCH’s ultimate use might be in sensing out other disease-causing pathogens. Quick, cheap cancer blood test is not far away “The detection of gastrointestinal cancers and precancerous lesions is an attractive clinical opportunity to apply this invention.” “We weren’t even sure if using bacteria as a sensor for mammalian DNA was even possible,” says Professor Jeff Hasty, UCSD’s co-senior author on the research. Although it’s a long way from human trials, researchers are excited by the outcomes. The system has been labelled CATCH (Cellular Assay of Target CRISPR-discriminated horizontal gene transfer), with the results of its test in animal models published in Science. ![]() ![]() The researchers were then able to read a signal from the bacteria to identify its interaction with cancerous KRAS. baylyi using CRISPR to sense, align with and integrate the colorectal cancer-promoting gene KRAS into its own DNA. The international collaboration between researchers from the University of California San Diego (UCSD), South Australian Health and Medical Research Institute (SAHMRI) and University of Adelaide modified Acinetobacter baylyi to sense DNA released by colorectal tumours, which floats freely outside of the cancer within the body.ĭrawing on bacteria’s ability to obtain new genetic information by interacting with other species and their environment – known as horizontal gene transfer – the group modified A. ![]() Scientists have taken inspiration from nature to engineer a bacteria that can detect gastrointestinal cancers and precancerous lesions in animal models. ![]()
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